Osteosarcoma in a Dinosaur

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Seper Ekhtiari, Kentaro Chiba, Snezana Popovic, Rhianne Crowther, Gregory Wohl, Andy Kin On Wong, Darren H Tanke, Danielle M Dufault, Olivia D Geen, Naveen Parasu, Mark A Crowther, David C Evans, Lancet Oncology. Aug 2020; 21(8):1021-1022.

EXCERPT

First case of osteosarcoma in a dinosaur: a multimodal diagnosis

Osteosarcoma is a primary bone malignancy with a worldwide incidence of 3·4 cases per million people per year. In humans, the incidence of osteosarcoma peaks in the second decade of life, which is thought to be related to the rapid growth velocity of bone at this age. To date, the cause, genetic alterations, oncogenic events, and evolutionary history of osteosarcoma are poorly understood, thus limiting further advancements in genome-informed targeted therapy for osteosarcoma.